alk- negative anaplastic large cell lymphoma of bone

ALK- negative Anaplastic Large Cell Lymphoma of Bone

ALK- negative Anaplastic Large Cell Lymphoma of Bone

Introduction Primary bone lymphoma (PBL) is a rare disease that was first described by Oberling in 1928.1 The vast majority of PBL cases are non-Hodgkin lymphoma (NHL), whereas primary Hodgkin lymphoma (HL) of bone is extremely rare. PBL constitutes 7% of all malignant bone tumors, 4-5% of all extranodal NHL, and less than 1% of all malignant lymphomas.2-5 Patients with primary NHL of bone comm...

ALK-negative anaplastic large-cell lymphoma.

Pathobiology of ALK-negative anaplastic large cell lymphoma

The authors revise the concept of ALK-negative anaplastic large cell lymphoma (ALCL) in the light of the recently updated WHO classification of Tumors of Hematopoietic and Lymphoid Tissues both on biological and clinical grounds. The main histological findings are illustrated as well as the phenotypic, molecular and clinical characteristics. Finally, the biological rationale for possible innova...

Pathobiology of ALK+ anaplastic large-cell lymphoma.

Anaplastic large-cell lymphoma (ALCL) was initially recognized on the basis of morphologic features and the consistent expression of CD30. It then became evident that the majority of these tumors are derived from lymphoid cells of T or null immunophenotype. The subsequent finding that t(2;5)(p23;q35) occurs in 40% to 60% of ALCL patients established a distinct clinicopathologic entity. This chr...

Primary gastric anaplastic lymphoma kinase-negative anaplastic large-cell lymphoma

INTRODUCTION Most primary stomach lymphomas are now recognized to originate from B-cell. Primary gastric anaplastic lymphoma kinase (ALK)-negative anaplastic large-cell lymphoma (ALCL) as shown in this case is very rare. CASE REPORT A 59-year-old man presented with a 1-month history of epigastric pain. Computed tomography showed a tumor in the stomach with perigastric lymphadenopathy. Biopsy ...